Formaldehyde, Hematotoxicity, and Chromosomal Changes—Response
نویسندگان
چکیده
منابع مشابه
Occupational Exposure to Formaldehyde, Hematotoxicity and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells – Letter
We read with interest the article by Zhang and coworkers (1). This study was performed to determine whether formaldehyde exposure disrupts the hematopoietic function and produces leukemia-related chromosome changes in exposed humans. The results might point to a yet unknown carcinogenic mode of action of formaldehyde leading to leukemia. Indeed, a working group at the IARC referred to this stud...
متن کاملOccupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells.
There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of leukemia. However, the biological pla...
متن کاملMapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation.
Gene regulation is a complex process. Numerous factors appear to be required for the accurate temporal and spatial regulation of each gene. Often these factors are assembled into multiprotein complexes, contributing to specific gene regulation events. Understanding how all these factors are organized in the chromosome and how their function is regulated in vivo is a challenging task. One of the...
متن کاملHematotoxicity and carcinogenicity of benzene.
The hematotoxicity of benzene exposure has been well known for a century. Benzene causes leukocytopenia, thrombocytopenia, pancytopenia, etc. The clinical and hematologic picture of aplastic anemia resulting from benzene exposure is not different from classical aplastic anemia; in some cases, mild bilirubinemia, changes in osmotic fragility, increase in lactic dehydrogenase and fecal urobilinog...
متن کاملHematotoxicity and carcinogenicity of inhaled benzene.
CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000 ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling 10 ppm produced no hematologic effects; 25 ppm induced a significant lymphopenia. Inhalation of 100, 300, and 400 ppm produced dose-dependent decreases in blood lymphocytes, bone marrow cellularity, marrow content of s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2018
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-17-0804